Collagen Glossary
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Hydroxylysine

Hydroxylysine is a remarkable amino acid that holds a unique status as it is exclusively found in collagen. Alongside hydroxyproline, hydroxylysine is categorized as a modified amino acid, and its presence is one of the distinguishing features of collagen protein. This amino acid plays a critical role in collagen’s structural integrity and functionality, contributing to the unique properties of collagen that make it essential for connective tissues, skin, and various bodily functions.

A noteworthy aspect of hydroxylysine is its synthesis, which requires the presence of vitamin C. Vitamin C, also known as ascorbic acid, is an essential cofactor in the enzymatic reactions that lead to the formation of hydroxylysine. Without an adequate supply of vitamin C, the synthesis of hydroxylysine within collagen is impaired, potentially affecting the quality and functionality of collagen in the body. Therefore, the interplay between hydroxylysine and vitamin C underscores the importance of a balanced diet and adequate nutrient intake in supporting collagen production and overall health. Understanding the role of hydroxylysine in collagen highlights its significance as a specialized amino acid that contributes to the structural and functional attributes of this essential protein in the body.

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